Kei-apple-mediated NiO nanoparticles and biological studies: anti-inflammatory and cytotoxicity study against HeLa and HEK 293 cell lines.

Abstract Nickel oxide (NiO) nanoparticles are gaining popularity in multiple fields owing to their useful properties. The application biomedicine has been further enhanced by combining them with plant extracts that possess unique biological In this report, NiO were synthesized mediating the reaction process leaf of Kei-apple ( Dovyallis Caffra ), a local fruit tree found South Africa. Various characterization techniques such as x-ray diffraction (XRD), V–Vis spectroscopy (UV–Vis), transmission electron microscope (TEM), Scanning (SEM), and Energy dispersive analysis (EDX) employed establish different physicochemical properties prepared material. XRD report obtained confirmed formation an average crystallite size 9 mm. Furthermore, microscopic showed material possessed spherical-shaped structure, diameter sizes smaller than 27.18 nm (average about 11 nm). purity was shown EDX analysis, which primary composition only elemental constituents nanoparticles. exhibited good cytotoxicity comparable 5-Fluorouracil both Human embryo kidney (HEK 293) cervical cancer (HeLa) cell lines, half maximal inhibitory concentration (IC 50 ) value 0.00015 13.8 μ g ml −1 , respectively. anti-inflammatory study, on other hand, weak effect used Bovine serum albumin denaturation assay. finding here thus suggests mediated can be safely without causing any appreciable harm human body due specificity cancerous line observed viability non-cancerous embryonic cells.